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WT1—与发育有关的肿瘤抑制基因 被引量:3

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摘要 肾母细胞瘤(或称Wilms’瘤,简称WT)是一种较为常见的儿科实体瘤,发病率约为1/10,000,分散发性和家族性两种肿瘤类型。该肿瘤发生于肾脏,肿瘤细胞类型既包括未分化或芽基细胞,又包括基质及上皮成分。这几种细胞的相对比例有个体差异,有的显示出组织学亚型。流行病学和遗传学分析揭示WT的发生与肿瘤抑制基因的失活有关。与视网膜母细胞瘤(RB)类似。
出处 《细胞生物学杂志》 CSCD 1994年第4期158-164,共7页 Chinese Journal of Cell Biology
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  • 1Wang Z Y,Proc Natl Acad Sci USA,1993年,90卷,8896页
  • 2Wang Z Y,J Biol Chem,1992年,267卷,21999页
  • 3Wang Z Y

同被引文献37

  • 1李雪丹,王晓枫,谭芳.卵巢卵泡膜细胞瘤的CT诊断[J].中华放射学杂志,2005,39(5):535-537. 被引量:74
  • 2Call KM,Glaser T,Ito CY,et al. Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus[J]. Cell, 1990,60( 3 ) : 509-520.
  • 3Klattig J,Sierig R,Kruspe D,et al. Wilms' tumor protein Wtl is an activator of the anti-Mullerian hormone receptor gene Amhr2[J]. Mol Cell Biol, 2007,27(12) :4355-4364.
  • 4Al-Hussaini M, Stockman A, Foster H,et al. WT-1 assists in distinguishing ovarian from uterine serous carcinoma and in distinguishing between serous and endometrioid ovarian carcinoma[J]. Histopathology, 2004,44( 2 ) : 109- l 15.
  • 5Scharnhorst V,van der Eb AJ,Jochemsen AG. WT1 proteins: functions in growth and differentiation[J]. Gene,2001,273(2):141-161.
  • 6Lee SB,Haber DA. Wilms tumor and the WT1 gene[J]. Exp Cell Res, 2001,264( 1 ) :74-99.
  • 7Gao F,Maiti S,Alam N,et al. The Wilms tumor gene,Wtl,is required for Sox9 expression and maintenance of tubular architecture in the developing testis[J]. Proc Natl Acad Sci U S A,2006,103 (32): 11987-11992.
  • 8Nocito A L, Sarancone S, Bacchi C, et al. Ovarian thecoma:clinicopathological analysis of 50 cases[J]. Ann Diagn Pathol, 2008, 12(1):12-16.
  • 9Schenkman N S, Moul J W, Nicely E R, et al. Synchronous bi- lateral testis tumor: mixed germ cell and theca cell tumor[J]. Urology, 1993, 42(5) :593-595.
  • 10Shashi V,Golden W L,von Kap Herr C, et al. Interphase fluo- rescence in situ hybridization for trisomy 12 on archival ovarian sex cord-stromal tumors[J]. Gynecol Oncol, 1994, 55 (3 Pt 1): 349-354.

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