急性心肌梗死患者溶栓前后QT离散度的变化

Variations of QT Dispersion on before and after Thrombolysis in Patients with Acute Myocardial Infarction

目的:观察急性心肌梗死(AMI)患者溶栓前后QT离散度(QTdispersion,QTd)的变化及早期再灌注对QTd的影响。方法:对61例AMI患者给予尿激酶静脉溶栓治疗,予溶栓前及溶栓2h后同步记录18导联心电图,分别测量成功组及失败组的QTd,并进行前后比较。结果:溶栓后再通41例,溶栓后未通20例。血管未通组其QTd较前减少,但无统计学意义(P>0.05),溶栓后再通组其QTd较血管未通组降低程度更大,有统计学意义(P<0.01)。结论:QTd可作为评价AMI患者溶栓后判断溶栓成功与否的一项临床早期参考指标。

Objective:To evaluate the variations of QT dispersion(QTd) before and after intravenous thrombolysis and the effects of early reperfusion in patients with acute myocardial infarction(AMI). Methods:QTd was measured before and after intravenous thrombolytic therapy in 61 patients. A synchronized record of 18 lead cardiograph was done before and 2 hours after the treatment. The QTd was calculated. Results:QTd was significantly prolonged in patients with AMI compared with control group (P < 0.001). QTd decreased more significant and quicker in reperfusion group compared with non reperfusion group (P < 0.01). Conclusion:Successful thrombolytic therapy and recovery of blood reprefussion as early as possible may markedly reduce QTd.