摘要
目的 :探讨新生儿黄疸在未致胆红素性脑病之前所致CNS损伤及对神经系统发育的远期影响 .了解胆红素对CNS损伤与日龄及浓度之间的关系 ,并针对CNS损伤进行早期治疗、干预 ,以减轻或避免胆红素对CNS损伤及神经系统的远期影响 .方法 :对 4 70例新生儿黄疸和 30例足月正常儿在新生儿期第 6～ 7d采用NBNA评分 ,然后分别在 1、 3、 6、 12月采用Amiel-Tison法对研究对象进行神经系统发育的监测 .结果 :出生后 7d内血中胆红素浓度≥ 171μmol/L的婴儿的神经系统发育障碍明显大于生后 7d内胆红素 <171μmol/L的婴儿 ,P <0 0 1.结论 :新生儿黄疸对CNS损伤及神经系统发育的远期影响与婴儿日龄及胆红素浓度有关 ,与黄疸持续时间无明显相关性 ;早产儿血中胆红素对CNS损伤及发育的远期影响的阈值低于足月儿 ;早期发现治疗、干预能减轻或避免胆红素对CNS损伤及神经系统发育的远期影响 .
Objective: To study brain damage before Kermicterus and a long term effect of neonatal jaundice on nervous development of infants, to find out the relationship between damage of CNS derived from bilirubin and days of neonates and bilirubin concentration, and to take measures of early control and prevention to avoid the occurrence of the damage in infants.Methods: 470 full-term with jaundice, 30 full-term without jaundice were examined using NBNA at 6～7 days after birth, then using Amiel-Tison in 1, 3, 6, month.Results: In 7 days after birth,the infants whose bilirubin concentration ≥171μmol/L had obviously obstruction of CNS development compared to these whose bilirubin concentration <171μmol/L.Conclusion: The damage degree of bilirubin to CNS and long term effect on CNS development are related to standing term and concentration of bilirubin.Early taking the effective measures of control and prevention is very important.
出处
《昆明医学院学报》
2005年第1期42-46,共5页
Journal of Kunming Medical College
基金
云南省卫生厅资助项目 (2 0 0 0 - 12 0 3)
