期刊文献+

与多药耐药相关的细胞信号通路新药物 被引量:2

Some new signaling-oriented drugs related to MDR
下载PDF
导出
摘要 多药耐药的原因之一是肿瘤细胞对药物引起的细胞凋亡有耐受。药物逆转这种耐受的一个靶位是细胞信号传导通路。现简述与细胞凋亡及存活相关的信号传导通路及几种以这些通路为靶位的药物。
作者 曹广生 焦波
出处 《国外医学(肿瘤学分册)》 2005年第3期190-193,共4页 Foreign Medical Sciences (Cancer Section)
基金 山东省卫生厅资助项目(2001CA2CAA2)
  • 相关文献

参考文献18

  • 1Kasimir Bauer S, Beelen D,Flasshove M,et al. Impact of the expression of P glycoprotein, the multidrug resistance- related protein, bcl-2, mutant p53, and heat shock protein 27 on response to induction therapy and long-term survival in patients with de novo acute myeloid leukemia. Exp Hematol,2002,30( 11 ): 1302-1308.
  • 2Tsuruo T. Molecular cancer therapeutics: recent progress and targets in drug resistance. Intern Med,2003,42 (3) :237-243.
  • 3Chinnaiyan AM. The apoptosome: heart and soul of the cell death machine. Neoplasia,1999,1 (1) :5-15.
  • 4Dijkers PF,Medema RH,Lammers JW,et al. Expression of the proapoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR- L1. Curr Biol, 2000,10 (19): 1201 - 1204.
  • 5Taylor ST, Hickman JA, Dive C. Epigenetic determinants of resistance to etoposide regulation of Bcl- x (L) and Bax by tumor microenvironmental factors. J Natl Cancer Inst,2000, 92 (1): 18-23.
  • 6English J,Pearson G,Wilsbacher J, et al. New insights into the control of MAP kinase pathways. Exp Cell Res, 1999, 253 (1): 255-270.
  • 7Vanhaesebroeck B, Alessi DR. The PI3K-PDKI connection: more than just a road to PKB. Bioche J,2000, 346(pt3) :561-576.
  • 8Knuefermann C, Lu Y, Liu B, et al. HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.Oncogene,2003,22(21 ) :3205-3212.
  • 9Favata MF, Horiuchi KY, Manos E J, et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem,1998,273 (29): 18623-18632.
  • 10Sebolt Leopold JS,Dudley DT, Herrera R,et al. Blockade of the MAP kinase pathway suppresses growth of colon tumours in vivo.Nat Med,1999, 5(7) :810-816.

同被引文献26

引证文献2

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部