羧甲基壳聚糖银噻苯咪唑的制备及其抑菌性能

Preparation and Antimicrobial Activity of Carboxymethyl Chitosan-Ag-tiabendazole

研究了一种新型广谱复合抗菌剂羧甲基壳聚糖银噻苯咪唑的制备与性能。抗菌实验结果表明:该新型复合抗菌剂能综合其单一组分抗菌剂或二元组分(羧甲基壳聚糖银和羧甲基壳聚糖噻苯咪唑)复合抗菌剂的优点,对大肠杆菌、金黄色葡萄球菌、白色念珠菌、黑曲霉和毛霉等代表性微生物的最小抑菌浓度分别为20×10-6、25×10-6、20×10-6、40×10-6和450×10-6 g/mL,具有优良的广谱抗菌效果;同时,克服了银离子的变色缺陷;银和噻苯咪唑分别与高分子羧甲基壳聚糖中的胺基和羧基发生了键合作用。

The preparation and antimicrobial activity of a new broad-spectral complex antimicrobial agent carboxymethyl chitosan-Ag-thiabendazole (CMCTS-Ag-TBZ) were studied. The results show that CMCTS-Ag-TBZ can integrate the antimicrobial characters of its monocomponent agents (CMCTS, Ag, TBZ) and bicomponents complex agents (CMCTS-Ag, CMCTS-TBZ). The minimal inhibition concentration (MIC) to some typically examples of bacteria and fungi, Escherichia coli, Staphylococcus aureus, Candida albicans, Aspergillus niger, Mucor sp., are 20×10-6, 25×10-6, 20×10-6, 40×10-6 and 450×10-6 g/mL, respectively, showing a very wonderful broad-spectrum inhibition to the chosen modeled bacteria and fungi. It is found to be able to prevent change in color of Ag+, the defect that occurs in the monocomponent Ag antimicrobial agent. The results of infrared spectrum analysis show that Ag and thiabendazole bind respectively to the amino group and carboxyl group of the CMCTS.