摘要
目的:观察综合性康复治疗时实验性大鼠急性脑梗死以及偏瘫的功能恢复。方法:雄性大鼠20只,用尼龙线堵塞法建立急性脑局部缺血而引起脑梗死偏瘫模型,随机分为综合康复治疗实验组(n=10,采用综合康复疗法和药物治疗相结合)和对照组(n=10,单纯应用药物疗法并制动),平均治疗20d,治疗前后评估各组大鼠肢体运动功能,并断头取脑,将梗死灶照相扫描输入Photoshop软件,比较梗死灶体积。结果:治疗前康复治疗组大鼠的肢体运动功能与对照组比较差异无显著性意义;治疗后康复治疗组大鼠肢体运动功能较治疗前和对照组均明显提高(P<0.01);但治疗后梗死灶体积较对照组无明显减小。结论:综合康复治疗可改善大鼠脑梗死偏瘫侧肢体运动功能,但未减小梗死灶体积。
Objective:To observe the effect of rehabilitation therapy on hemiplegia rats of cerebral ischemia. Method:20 male hemiplegia rats in model of cerebral middle artery blocked by nylon silk were divided into rehabilitation group and control group. Both groups′ motion ability was evaluated before and after 20d. The rats in both groups rats were killed,and their brain ischemia volume were compared. Result:Before therapy two groups had no observe difference. After 20 days therapy, the rehabilitation group′ motive ability increased vs before and vs the control group(P<0.01).There were no evident change in two groups′ ischemia volume.Conclusion:The rehabilitation therapy may improve hemiplegia rats′ motive ability, but the reason is not to decrease the block volume.
出处
《中国康复医学杂志》
CAS
CSCD
北大核心
2005年第2期98-99,共2页
Chinese Journal of Rehabilitation Medicine
关键词
康复
偏瘫
大鼠
脑梗死
治疗
实验观察
rehabilitation
hemiplegia
rats
cerebral infarction
