相转移催化一步合成三唑酮的研究

Studies on One-step Synthesis of Triadimefon by Phase Transfer Catalysis

研究了ＰＥＧ为固液相转移催化剂（ＰＴＣ），固体Ｋ＿２ＣＯ＿３为碱一步合成三唑酮。考察了二元溶剂，碱，ＰＴＣ，不同滴加方式对三唑酮收率的影响，结果表明：在适当条件下，三唑酮收率可达６５．４％。

Triadimefon(1)was prepared in one-step from 1,2,4-triazole,4-chlorophenol and α,α-dichloropinacolone under solid-liquid phase transfer catalysis condi-tions,Effects of reaction conditions such as different addition sequence,molecular weight ofPEG,base and bisolvent system on the yield of(1)were studied.Fair yield was obtainedwith PEG 600 and powdered potassium carbonate in toluene/methyl-isobutyl ketone(1:1 V/y)bi-solvent.