摘要
采用同位素示踪技术和蛋白质结合法研究了沙棘汁和沙棘油的抗癌机理。结果显示:沙棘汁对L_(7712)白血病、S_(180)肉瘤、腹水型肝癌等细胞的DNA、蛋白质合成均无抑制作用。沙棘油浓度在0.005~1.0mg/L时对L_(7712)白血病细胞DNA合成有抑制作用,且此时抑制率与浓度呈负相关。沙棘汁ip注射剂量为1/5LD_(50)时,沙棘汁对小鼠血浆cAMP含量略有提高。
The anti-tumour mechanisms of sea-buckthron juice and sea-buckthronoil were studied by means of isotopic technique and protein binding method.The resultsshowed that sea-buckthron juice couldn' t inhibit the DNA synthesis and the protein synythe-sis of Leukemia 7712,Sarcoma 180 and Ascitic hepatoma;while sae-buckthron oil, whoseconcentration restricted in 0.005~1.0μg/ml,could greatly inhibit the DNA synthesis ofLeukemia 7712, and the inhibition was negatively correlative with the concentration of sea-buckthron oil.The plasma cAMP level of mice at 1/5 LD_(50)(1. 88 g/kg·d×5 d) of sea buck-thron juice increased slightly.
出处
《厦门大学学报(自然科学版)》
CSCD
北大核心
1994年第4期548-551,共4页
Journal of Xiamen University:Natural Science
关键词
沙棘汁
沙棘油
DNA
蛋白质
癌细胞
Sea-buckthron juice
Sea-buckthron oil
Leukemia 7712
Sarcoma180
Ascitic hepatoma
cAMP
DNA
Protein