摘要
目的 研究染色体分析在精子库供精者 (Donor)筛查中的作用 ,防止供精人工受精后出生遗传病患儿。 方法 应用染色体G显带 ,对 70 6例Donor的染色体进行分析。 结果 70 6例Donor染色体中 ,染色体异常 12例 [inv(9) ] ,共有多态 76例 (Yqh + 73例 ,16qh + 3例 )。 结论 供精者个体存在染色体异常且以 9号染色体倒位为主 ,供精者个体存在较高频率的大Y ,其临床意义有待于积累更多资料。
Objective To study the effect of chromosomal factors on sperm bank screening and prevent baby born with gentic abnormality from artificial insemination. Method Karyotypes of 706 donor were analyzed by chromosome G banding. Result Abnormal Karyotypes were found in 12 cases and the abnormal rate was 1.70%.Polymorphism was found in 76 cases and the polymorphism rate was 10.76%. Conclusion Chromosome 9 abnormality is an important factor in donors, and there is a high big Y chromosome rate in donors, whose clinical significance is to be studied with more accumulation of data.
出处
《实用预防医学》
CAS
2005年第1期18-19,共2页
Practical Preventive Medicine
基金
国家自然科学基金 (30 1 70 4 80
30 4 70 884)
