辛伐他汀对不稳定型心绞痛患者的C反应蛋白、白细胞介素-6和纤维蛋白原水平的影响(英文)

Effects of simvastatin to levels of CRP, IL-6 and FIB in serum of unstable angina pectoris (UAP) patients

目的观察辛伐他汀对不稳定型心绞痛(UAP)患者血清C反应蛋白(CRP)、白细胞介素-6(IL-6)、纤维蛋白原(FIB)等的影响。方法选择UAP患者60例,随机分为辛伐他汀组和对照组,每组30例。对照组常规给药,辛伐他汀组在此基础上加服辛伐他汀20mg,每晚1次,疗程8周。结果治疗后辛伐他汀组血清中CRP、IL-6、FIB浓度明显降低,和对照组相比P<0.05,有显著性差异,并且与降脂作用无关。结论辛伐他汀除降脂作用外,具有抗炎、抗血栓形成作用。

To investigate the effects of simvastatin to the levels of C-reaction protein (CRP) and interleukin-6(IL-6) and fibrinogen in serum of unstable angina pectoris (UAP) patients. 60 UAP inpatients were randomized. The cases were randomly divided into two groups, simvastatin group and control group. There were 30 patients in each group. The patients of control group were administration routine. Besides the simvastatin group took 20 mg simvastatin every night for about 8 weeks. The concentrations of CRP, IL-6 and FIB decreased obviously in serum of simvastatin group patients after administration. Compared with control group there were significantly different (P <0.05). There were no correlations with blood lipid decrease by simvastatin. [Conclusion] In addition to decrease the concentration of blood lipid, simvastatins have the roles of anti-inflammation and anti-thrombosis. It points out that simvastatin may prevent and cure coronary heart disease (CHD).