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海洋异臭椿类三萜化学结构与生物活性的关系 被引量：2

The Structure-Activity Relationship of Isomalabaricans
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摘要 海洋异臭椿类三萜化合物是一类化学结构特殊并具有多种生物活性的海洋天然产物。近年来国内外学者对海绵等海洋生物中的异臭椿类三萜化合物及其生物活性进行较多研究。 Isomalabaricans are typical triterpenes isolated from marine sponges and other marine organisms, and they showed potential activities toward tumor cell lines. The relationship between chemical structures and biological activities of isomalabarican triterpene is described in the review.
作者 吕芳 林文翰
机构地区 北京大学天然药物及仿生药物国家重点实验室
出处 《中国天然药物》 SCIE CAS CSCD 2005年第2期74-77,共4页
基金 国家高技术计划海洋 863课题资助(No .2 0 0 1AA62 4 0 30 )~~
关键词 海洋药物 异臭椿类三萜 生物活性 化学结构 药效学实验 Marine organisms Isomalabarican triterpene Chemical structures and biological activities
分类号 R282.77 [医药卫生—中药学] R284 [医药卫生—中药学]
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参考文献11

  • 1邓松之.海洋臭椿类三萜(malabaricane triterpenes)的研究进展[J].中国海洋药物,2004,23(1):37-41. 被引量：4
  • 2[2]Tsuda M, Agemi K, et al. Stelliferins A-F, New Antineoplastic isomalabaricane triterpenes from the okinawan marine sponge Jaspis stellifera[J]. Tetrahedron, 1991, 47(12): 2181-2194.
  • 3[3]Su JY, Meng YH, Zeng LM, et al. Stellettin A, A new triterpenoid pigment from the marine sponge Stelletta tenuis[J]. J Nat Prod, 1994, 57(10): 1450-1451.
  • 4[4]Ryu G, Matsunaga S, Fusetani N. Globostellatic acids A-D, new cytotoxic isomalabaricane triterpenes from the marine sponge Stelletta globostellatta[J]. J Nat Prod, 1996, 59(5): 512-514.
  • 5[5]Mcormick JL, Mckee TC, Cardellina JH, et al. Cytotoxic triterpenes from a marine sponge Stelletta sp[J]. J Nat Prod, 1996, 59(11): 1047-1050.
  • 6[6]Tasdemir D, Mangalindan GC, Concepcion GP, et al. Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata[J]. J Nat Prod, 2002, 65(2): 210-214.
  • 7[7]Tawnya C. Mckee, Heidi R, et al. Isolation and characterization of new Anti-HIV and cytotoxic leads from plants, marine, and microbial organisms[J]. J Nat Prod. 1997, 60(5): 431-438.
  • 8[8]Zampella A, D′ Aura MV, Debitus C, et al. New isomalabaricane derivatives from a new species of Jaspis sponge[J]. J Nat Prod, 2000, 63(7): 943-946.
  • 9[9]Oku N, Matsunaga S, Wada S, et al. New isomalabaricane triterpenes from the marine sponge Stelletta globostellatta that Induce Morphological changes in Rat Fibroblasts[J]. J Nat Prod, 2000, 63(2): 205-209.
  • 10[10]Meragelman KM, Mckee TC, Boyd MR. New cytotoxic isomalabaricane triterpenes from the Sponge Jaspis species[J]. J Nat Prod, 2001, 64(3): 389-392.

二级参考文献17

  • 1Chawla A, Dev S. A New Class of Triterpenoids from Ailanthus malabarica DC Derivatives of Malabaricane[J]. Tetrahedron Lett, 1967, 8(48) : 4837.
  • 2Sobti RR, Dev S. A Direct Correlation of (+)-malaobaricol with ( + )-ambreinolide [J]. Tetrahedron Lett,1968, 9(18) ,2215.
  • 3Sharpless KB. d, l-Malabaricanediol, the first Cyclic Natural Product Derived from Squalene in a Nonenzymic Process [J]. J Am Chem Soc, 1970, 92(23):6999.
  • 4Paton WF, Paul IC, Bajaj AG, et al. The Structure of Malabaricol [J]. Tetrahedron Lett, 1979, 20 (43):4153.
  • 5Ravi BN, Wells RJ, Croft KD. Malabaricane Triterpenes from a Fijian Collection of the Sponge Jaspis stellifera[J], y OrR Chem., 1981, 46(10), 1998.
  • 6Ravi BN. , Wells RJ. Malabaricane Triterpenes froma Great Barrier Reef Collection of the Sponge Jaspis stellifera[J]. Aust J Chem, 1982, 35(1):39.
  • 7McCabe T, Clardy J, Minale L, et al. A Triterpenoid Pigment with the Isomalabaricane Skeleton from the Sponge Stelletta sp. [J]. Tetrahedron Lett, 1982, 23(33), 3307.
  • 8Tsuda M, Ishibashi M, Agemi K, et al. Stelliferins A-F, New Antineoplastic Isomalabaricane Triterpenes from Okinawan Marine Sponge Jaspis stelli f era [ J ]. Tetrahedron, 1991, 47(12): 2181.
  • 9Su JY, Meng YH, Zeng LM, et al. Stellettin A, ANew Triterpenoid Pigment from the Marine Sponge Stelletta tenuis [J].J Nat Prod, 1994, 57(10): 1450.
  • 10Ryu G, Matsunaga S, Fusetani N. , Globostellatic Acids A-D, New Cytotoxie Isomalabaricane Triterpenes from the Marine Sponge Stelletta globostellatta [J]. J NatProd, 1996, 59(5):512.

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中国天然药物
2005年 第2期

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