(S)-N-(2-氨基苯基)四氢吡咯-2-甲酰胺的合成及其在直接不对称Aldol反应中的应用

Preparation of (S)-N-(2-aminophenyl)-pyrrolidine-2-carboxamide and its application in direct asymmetric Aldol reaction

以(S) Proline为原料三步合成(S)-N-(2-氨基苯基)四氢吡咯-2甲酰胺1,总产率64.25%.并用于催化直接不对称Aldol反应,产率65%～84%,ee值26.5%～40.7%.

(S)-N-(2-aminophenyl)pyrrolidine-2-carboxamide which was prepared from (S)-proline (total yield 64.25% for three steps) was applied in direct asymmetric Aldol reaction(yield 65%～84%,ee 26.5%～40.7%).