摘要
目的研究头孢噻肟钠与维生素B6注射液在5%葡萄糖注射液中配伍的稳定性.方法运用紫外分光-系数倍率法考察头孢噻肟钠与维生素B6注射液配伍后6 h内含量变化情况,同时观察外观并测定pH值.结果头孢噻肟钠的线性范围为16~22 mg·L-1,平均回收率为99.99%,RSD为0.12%(n=5).头孢噻肟钠与维生素B6注射液配伍后3 h内,其配伍液的外观、pH值、含量无显著变化;4 h含量明显下降,5~6 h后配伍液的紫外扫描图谱发生显著变化.结论头孢噻肟钠与维生素B6注射液配伍后3 h内性质稳定,此结果可供临床合理用药时参考.
Aim To study the compatible stability of cefotaxime sodium and vitamin B 6 in glucose injection. Methods The content of cefotaxime sodium was determined by ultraviolet spectrophotometry. The change in the content, pH value appearance, and UV spectrophotometry were observed by room temperature storage. Results The linearity range for cefotaxime sodium was 16~22 mg·L -1 ;The rate of average recovery was 99.99%,with relative stardand deviation 0.12%(n=5);Under room temperature condition,the contents of cefotaxime sodium was changed significantly in 4 hours. Conclusion This experiment can be used for reference in clinical practice.
出处
《安徽医药》
CAS
2005年第3期169-170,共2页
Anhui Medical and Pharmaceutical Journal