卵巢上皮性肿瘤雌孕激素受体的单克隆抗体免疫组化研究

Immunohistochemical study of ER and PR in ovarian epithelial tumors.

利用抗雌激素受体（ＥＲ）和孕激素受体（ＰＲ）的两种单克隆抗体对３１例卵巢上皮性肿瘤新鲜冰冻标本进行ＡＢＣ法测定，ＥＲ、ＰＲ的阳性表达率分别为４５．２％和４８．４％，恶性肿瘤ＥＲ的含量高于良性者，ＰＲ在良、恶性肿瘤间未见有明显差异。提示：部分卵巢上皮性肿瘤属于激素依赖性肿瘤，对晚期卵巢癌可试用激素疗法。ＥＲ、ＰＲ在宫内膜样癌和浆液性癌的含量高于其它类型上皮性肿瘤，高分化者受体阳性率及含量高于低分化者；ＥＲ或ＰＲＦ阳性者预后好于阴性者，二者具独立的预后因素，且ＥＲ、ＰＲ双阳性者预后比ＥＲ阳性、ＰＲ阴性或ＥＲ阴性、ＰＲ阳性者好。

Using the monoclonal antibodies specific to estrogen receptor (ER)and progesterone receptor (PR), we have examined the expression of ER and PR in 31 fresh- frozen tissues from ovarian epithelial tumors.ER positive stain was found in 45.2% cases, while PR was 48.4%. ER positive rate was significantly higher in carcinomas than that benign tumors,however, no statistic difference was found with PR. ER and PR were more frequently positive in endometrioid and serous carcinomas than other histologic types. The contents of ER and PR were significantly associated with tumor grade, but not related to clinical stage. The expressions of ER and PR were all identified as independent prognostic factors and their simultaneous detection could improve the prognostic value. It was concluded that the status of receptors may become useful in selecting patients with ovarian cancer for endocrinal therapy.