传染性单核细胞增多症外周血B淋巴细胞CD_(21)的表达

Expression of CD_ 21 on Peripheral Blood B Lymphocytes in Children with Infectious Mononucleosis

目的 探讨外周血B淋巴细胞CD2 1 的表达在传染性单核细胞增多症 (IM)发病机制中的作用。方法 用流式细胞术测定IM患儿 38例、新生儿 1 4例、对照组 1 4例的外周血B淋巴细胞CD2 1 表达水平。结果 IM组外周血中B淋巴细胞比例、表达CD2 1 B淋巴细胞数及B淋巴细胞表达CD2 1 位点均高于 2个对照组 (P <0 .0 5 ,P <0 .0 1 )。结论 EB病毒 (EBV)感染可诱导B淋巴细胞持续高表达CD2 1 ,以利于病毒进入细胞并导致潜伏型感染和增殖性感染。

Objective To investigate the expression of CD_ 21 on peripheral blood B lymphocytes in children with infectious mononucleosis(IM).Methods The expression of CD_ 21 on B lymphocytes were analyzed with flow cytometry in IM group and two control groups.Results The ratio of B lymphocytes,the number of B lymphocytes expressing CD_ 21,and the number of CD_ 21 on B lymphocyte were significantly higher in IM group than two control groups(P<0.05,P<0.01).Conclusion Infection of Epstein-Barr virus (EBV) could induce B lymphocytes expression CD_ 21 with higher level, and benefit to EBV enter cells and lead to latent and proliferative infection.