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正在研究中的抗肿瘤新药9-硝基喜树碱 被引量：4

9-nitrocamptothecin,a new anti-tumor agent under development
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摘要 9-硝基喜树碱(9-NC)为一个半合成喜树碱衍生物,其药理作用主要表现为对拓扑异构酶Ⅰ的抑制。目前,对9-NC的研究已进入Ⅱ期或Ⅲ期临床试验,具有广泛的抗肿瘤活性,且毒性较低,是极具潜力的抗肿瘤新药。现对其药理作用、药动学、临床前研究等作一综述。 9-nitrocamptothecin(9-NC) is a semi-synthetic derivative of camptothecin, acted by inhibition of DNA topoisomerase (Topo Ⅰ). 9-NC is currently in Phase Ⅱ and Ⅲ clinical trials for variety of cancers. This paper presents the pharmacology, pharmacokinetics and pre-clinical studies of 9-NC.
作者 殷琦 张春燕 李长龄
机构地区 北京大学基础医学院 北京大学人民医院药剂科
出处 《中国新药杂志》 CAS CSCD 北大核心 2005年第2期226-230,共5页 Chinese Journal of New Drugs
关键词 9-硝基喜树碱 拓扑异构酶Ⅰ抑制剂 抗肿瘤药 9-nitrocamptothecin(9-NC) topoisomerase Ⅰ inhibitor anti-tumor agent
分类号 R979.12 [医药卫生—药品] R969.4 [医药卫生—药理学]
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参考文献28

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二级参考文献31

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中国新药杂志
2005年 第2期

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