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摘要 [通用名称]imatinib,甲磺酸伊马替尼[化学名称]4-[(4-甲基-1-哌嗪)甲基-]-N-{4-甲基-3-[(3-吡啶-2-嘧啶)
出处 《中国新药杂志》 CAS CSCD 北大核心 2005年第2期236-238,共3页 Chinese Journal of New Drugs
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  • 1Druker BJ, Talpaz M,Resta DJ, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia[J]. N Engl J Med ,2001,344(14): 1031 - 1037.
  • 2Kantarjian H, Sawyers C, Hochhaus A, et al. Phase Ⅱ study of STI571, a tyrosine kinase inhibitor in patients with resistant or refractory Philadelphia chromosome positive chronic myedloid leukemia[ J ]. Blood, 2000,96: 470a.
  • 3Hughes TP, Kaeda J, Branford S, et al. International Randomised Study of Interferon versus STI571 (IRIS) Study Group. Requency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia [ J ]. N Engl J Med ,2003,349(15): 1423 - 32.
  • 4Demetri GD,Mehren M,Blanke CD, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors[J]. N Engl J Med, 2002,347(7) :472 - 480.
  • 5Weisberg E,Griffin JD. Mechanism of resistance to the ABL tyro sine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines[ J ]. Blood, 2000,1,95 ( 11 ): 3498 - 505.
  • 6Gorre ME, Mohammed M, Ellwood K, et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification[ J ]. Science, 2001,293 (5531): 876 - 880.

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