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细胞凋亡通路及转录调控中的Daxx 被引量：3

Daxx of apoptotic pathway and transcriptional regulation in cell
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摘要 Daxx is found in the nucleus where it localizes to PML oncogenic domains (PODs). Its multiple domains can interact proteins involved in transcriptional regulation and apoptotic signal transduction. In addition, Daxx is associated with viral infection、tumorigenesis and embryonic development. Daxx is found in the nucleus where it localizes to PML oncogenic domains (PODs). Its multiple domains can interact proteins involved in transcriptional regulation and apoptotic signal transduction. In addition, Daxx is associated with viral infection、tumorigenesis and embryonic development.
作者 苏波 万艳平 廖端芳
机构地区 南华大学药物药理研究所
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2005年第3期617-620,共4页 Chinese Journal of Pathophysiology
基金 国家自然科学基金资助项目 (No .30 4 70 719)
关键词 DAXX 细胞凋亡 转录调控 Daxx Apoptosis Transcriptional regulation
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献21

  • 1万艳平,谭立志,刘传爱,吴移谋,Colosimo April,廖代清.腺病毒E1B55ku癌蛋白打破hDaxx与PML在细胞核的共定位[J].微生物学杂志,2001,21(4):46-48. 被引量：8
  • 2Yang X, Khosravi FR, Chang HY, et al. Daxx, a novel Fas-binding protein that activates JNK and apoptosis[J]. Cell, 1997, 89(7): 1067-1076.
  • 3Pluta AF, Earnshaw WC, Goldberg IG. Interphase-specific association of intrinsic centromere protein CENP-C with hDaxx, a death domain-binding protein implicated in Fas-mediated cell death[J]. Cell Sci, 1998, 111(14) : 2029-2041.
  • 4Ko YG, Kang YS, Park H, et al. Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm[J]. J Biol Chem, 2001, 276(42): 39103-39106.
  • 5Charette SJ, Lavoie JN, Lambert H, et al. Inhibition of Daxx-mediated apoptosis by heat shock protein 27[J]. Mol Cell Biol, 2000, 20(20): 7602-7612.
  • 6Muromoto R, Yamamoto T, Yumioka T, et al. Daxx enhances Fas-mediated apoptosis in a murine pro-B cell line, BAF3[J]. FEBS Lett, 2003, 540(1-3): 223-228.
  • 7薛冬英,洪嘉禾.转化生长因子β的丝裂原激活蛋白激酶通路及其对细胞的调节作用[J].中国病理生理杂志,2003,19(10):1432-1436. 被引量：3
  • 8Shinoda S, Skradski SL, Araki T, et al. Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death[J] . Eur J Neurosci, 2003, 17(10): 2065-2076.
  • 9Zhong S, Salomoni P, Ronchetti S, et al. Promyelocytic Leukemia Protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis[J]. J Exp Med, 2000, 191(4): 631-640.
  • 10Michaelson JS, Bader D, Kuo F, et al. Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development[J]. Genes Dev, 1999, 13(15): 1918-1923.

二级参考文献8

  • 1[1]Wienzek, S., Roth, J. and Dobbelstein, M. E1B 55-kilodalton oncoproteins of adenovirus types 5 and 12 inactivate and relocalize p53, but not p51 or p73, and cooperate with EAorf6 proteins to destabilize p53[J]. J. Virol., 2000,74:193～202.
  • 2[2]Punga, T. and Akusjarvi, G. The adenovirus-2 E1B-55K protein interacts with a mSin3A/histone deacetylase 1 complex[J]. FEBS Letters, 2000,476:248～252.
  • 3[3]Liu, y., Colosimo, A.L., Yang, X.J., etal. Adenovirus E1B 55-kilodalton oncoprotein inhibits p53 acetylation by PCAF[J].Mol. & Cell. Biol., 2000,20:5540～5553.
  • 4[4]Ishov, M., A., Sotnikov, G., A., Negorev, D., et al. PML is critical for ND10 formation and recruits the PML-interacting protein Daxx to this nuclear structure when modified by SUMO-1[J].J. Cell Biology, 1999,147: 221 ～ 233.
  • 5[5]Li, H., Leo, C., Zhu, J., et al. Sequestration and inhibition of Daxx-mediated transcriptional repression by PML[J]. Molecular and cellular biology, 2000,20:1784 ～ 1796.
  • 6谭立志,万艳平,吴移谋,刘传爱,余敏君,尹卫国,廖端芳.hDaxx与细胞肿瘤抑制子p53在体内外的相互作用[J].微生物学杂志,2001,21(4):32-34. 被引量：9
  • 7万艳平,谭立志,刘传爱,吴移谋,Colosimo April,廖代清.腺病毒E1B55ku癌蛋白打破hDaxx与PML在细胞核的共定位[J].微生物学杂志,2001,21(4):46-48. 被引量：8
  • 8赵俊芳,刘成,刘成海.转化生长因子β胞内信号转导与Smads蛋白[J].中国病理生理杂志,2002,18(3):321-325. 被引量：37

共引文献9

同被引文献39

  • 1李春蕊,黄伟,刘文励,孙汉英,周剑锋.Daxx在急性白血病的表达及意义[J].中国组织化学与细胞化学杂志,2005,14(6):618-622. 被引量：3
  • 2李金丽,万艳平.Daxx研究进展[J].医学分子生物学杂志,2006,3(2):139-142. 被引量：2
  • 3LINDSAY C R,MOROZOV V M,ISHOV A M.PML NBs(ND10)and Daxx:from nuclear structure to protein function[J].Front Biosci,2008,13:7132-7142.
  • 4SHIH H M,CHANG C C,KUO H Y,et al.Daxx mediates SUMO-dependent transcriptional control and subnuclear compartmentalization[J].Biochem Soc Trans,2007,35:1397-1400.
  • 5LIN D Y,SHIH H M.Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration[J].Biol Chen,2002,28:25446-25456.
  • 6NEFKENS I,NEGOREV D G,ISHOV A M,et al.Heat shock and Cd2+ exposure regulate PML and Daxx releae from ND10 by independent mechanisms that modify the induction of heat-shock proteins 70 and 25 differently[J].J Cell Sci,2003,116(Pt3):513-524.
  • 7LIN D Y,HUANG Y S,JENG J C,et al.Role of SUMO-interacting motif in Daxx SUMO modification,subnuclear localization,and repression of sumoylated transcription factors[J].Mol Cell,2006,3:341-354.
  • 8KHELIFI A F,D'ALCONTRES M S,SALOMONI P.Daxx is required for stress-induced cell death and JNK activation[J].Cell Death Differ,2005,7:724-733.
  • 9KUO H Y,CHANG C C,JENG J C,et al.SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx[J].Proc Natl Acad Sci USA,2005,4:16973-16978.
  • 10MUROMOTO R,SUGIYAMA K,TAKACHI A,et al.Phyical and functional interactions between Daxx and DNA methyltransferase 1-associated protein,DMAP1[J].J Immunol,2004,5:2985-2993.

引证文献3

二级引证文献2

中国病理生理杂志
2005年 第3期

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