葛根素对单侧肾切除糖尿病大鼠肾脏的保护作用被引量：9

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摘要　目的　探讨葛根素对单侧肾切除糖尿病大鼠(DN)肾脏的保护作用及机制。方法　葛根素治疗DN大鼠6周后,检测其体重、肾脏指数(肾重/体重)、尿微量白蛋白(Ualb)、血糖、血管紧张素Ⅱ(AngⅡ)含量及肾组织蛋白激酶C(PKC)活性、转化生长因子- β1(TGF- β1)和Ⅳ型胶原(CoⅣ)蛋白表达。结果　与DN组比较,葛根素治疗组大鼠体重、肾脏指数、Ualb明显减少,血糖和 AngⅡ含量下降,肾皮质胞膜PKC活性降低,肾组织中TGF- β1、CoⅣ蛋白表达下降。结论　葛根素可通过改善DN大鼠肾脏功能、降低血糖、Ang Ⅱ含量和肾皮质胞膜 PKC活性,下调 TGF- β1 蛋白表达,减少细胞外基质(ECM)的沉积,延缓DN的发生发展。

作者茅彩萍顾振纶曹莉

机构地区苏州大学医学院药理教研室

出处《江苏医药》 CAS CSCD 北大核心 2005年第3期223-225,共3页 Jiangsu Medical Journal

基金江苏省中医药管理局科研基金资助项目(H 028)

关键词葛根素保护作用糖尿病肾病肾切除术

分类号 R587.2 [医药卫生—内分泌] R699.2 [医药卫生—泌尿科学]

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参考文献2

1陈宽林.转化生长因子β_1与糖尿病肾病[J].医学综述,2002,8(11):664-665. 被引量：2
2茅彩萍,顾振纶.糖尿病肾病发病机制的研究进展[J].中国血液流变学杂志,2002,12(2):148-152. 被引量：16

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