计算机辅助组织工程:概况、范围和挑战(第一部分)

Computer Aided Tissue Engineering: Overview, Scope and Challenges(Part I)

计算机辅助技术结合生物学、工程学和信息科学在组织工程中应用已发展成一个崭新领域———计算机辅助组织工程(CATE)。这一新出现领域包括针对生物组织和器官替代物设计、仿真和制造的计算机辅助设计(CAD)、影像处理、建模的任意实体加工(SFF)和制造。本文就此领域的一些突出进展进行综述、介绍,尤其着重在计算机辅助组织建模、计算机辅助组织信息学和计算机辅助组织支架设计和加工三个方面。并特别从高分辨率非侵入性成像、基于影像的三维重建和基于CAD的组织模型重建技术的几个方面入手,对CATE建模发展的方法学进行了讨论。也将对组织工程中SFF技术的最新进展、生物蓝图模型对细胞及器官三维喷印的应用进行介绍。

Advances in computer-aided technology and its integration with biology, engineering, and information technology to tissue engineering application have developed a new field of computer-aided tissue engineering(CATE).This emerging field encompasses computer-aided design,imaging process, manufacturing, and solid freeform fabrication for modeling, designing, simulation, and manufacturing of biological tissue and organ substitutes. This paper presents some salient advances in this field, particularly in computer-aided tissue modeling, computer-aided tissue informatics, and computer-aided tissue scaffold design and fabrication. Methodologies of development of CATE modeling from high resolution non-invasive imaging and image-based 3D reconstruction, and various reconstructive techniques for CAD based tissue modeling generation will be described. The latest development in solid freeform fabrication to tissue engineering and a framework of bio-blueprint modeling for 3D cell and organ printing will also be introduced.