摘要
目的测定比较系统性红斑狼疮(SLE)患者[尤其是不同病理类型狼疮肾炎(LN)患者]血浆中巨噬细胞衍生趋化因子(MDC)的水平,探讨其作为Th2型免疫反应标志物的变化及意义。方法利用酶联免疫吸附试验(ELISA)检测SLE患者46例(其中经肾活检确定病理分型的LN患者15例)以及类风湿关节炎(RA)患者16例和正常对照16名血浆MDC含量。结果未经治疗的SLE患者与经治患者、RA患者和正常对照组血浆中的MDC含量差异有统计学意义,SLE患者血浆MDC水平与系统性红斑狼疮疾病活动指数(SLEDAI)呈正相关。LN患者血浆中MDC含量与其病理类型存在明显的联系:Ⅱ型和Ⅲ型LN组高于Ⅳ型组。结论MCD可能在估计SLE的活动度和判断LN的类型上具有一定意义。SLE疾病进程与血浆中MDC水平密切相关。
Objective To investigate the significance of macrophage-derived chemokine (MDC) pre-dominantly expressed in Th2-type immune reaction by measuring the concentration of MDC in systemiclupus erythematous (SLE) patients with different pathology type lupus nephritis. Methods Plasma samples of MDC obtained from 46 SLE patients, 16 rheumatoid arthritis patients and 16 healthy control was determined by enzyme-linked immunosorbent assay (ELISA). Results There were significant differences in the plasma concentrations of MDC between the patients with untreated SLE and treated SLE, rheumatoid arthritis, and healthy controls. In addition, the plasma levels of MDC correlated with the class of lupus nephritis (higher in class Ⅱ or Ⅲ than in class Ⅳ). There was positive correlation between MDC concentration and SLEDAI score. Conclusion MDC may provide help in assessing the degree of disease activity in SLE and the pathological type of lupus nephritis. The development of SLE is closely related to the elevation of plasma MDC levels.
出处
《中华风湿病学杂志》
CAS
CSCD
2005年第3期142-144,共3页
Chinese Journal of Rheumatology
