术后早期肠内营养对胃肠肿瘤患者体液免疫的影响

Effect of Early Postoperative Enteral Nutrition on Humoral Immunity of Patients with Gastrointestinal Tumor

目的探讨术后早期肠内营养对胃肠肿瘤患者体液免疫的影响。方法将2003年6～12月本科收治的30例胃肠道肿瘤患者均分为肠内营养(EN)和肠外营养(PN)两组。EN组术后24小时内经鼻空肠管输注肠内营养液,PN组经外周静脉输注营养液,两组热卡、氮量相同。于术前(营养支持前)、术后第7天(营养支持后)检测体液免疫指标IgA、IgG、IgM、C3、C4和CH50。结果EN组体液免疫指标较营养支持前差异无显著性(P>0.05)。PN组IgA、IgG、IgM差异无显著性;但C3、C4、CH50营养支持前分别为(1.091±0.227)、(0.221±0.051)和(40.950±11.400)g/L,营养支持后分别为(0.782±0.233)、(0.162±0.058)和(32.440±9.355)g/L,支持后较支持前明显降低,差异具有显著性(P=0.002,0.009,0.049)。结论胃肠肿瘤术后早期肠内营养对改善机体体液免疫有一定作用。

Objective To observe the effect of early postoperative enteral nutrition on humoral immunity of patients with gastrointestinal tumor. Methods Thirty patients with gastrointestinal tumor were equally divided into EN group and PN group. Nutrition support was given in 24 hours after operation and con-tinued until day 7. All variables about humoral immunity were messured before operation and on pos-toperative day 7. Results C3 C4 and CH50 levels in PN group decreased significantly on postoperative day 7(P < 0.05) while no significant decrease in EN group(P > 0.05). There were no significant difference of IgA IgG IgM levels in both EN group and PN group. Conclusion Early postoperative enteral nutrition can improve the humoral immunity of patients with gastrointestinal tumor.