搏动性导管泵在绵羊心脏复苏中的应用(英文)

The application of pulsatile catheter pump support on cardiac resuscitation in sheep

目的 探讨搏动性导管 (pulsatilecatheter,PUCA)泵在心脏复苏中的应用 ,为临床抢救心跳骤停的患者提供一种新的思路。方法 健康绵羊 11只 ,致室颤心脏停跳行心脏复苏 ,根据有无PUCA泵辅助及辅助是否及时分三组 :无辅助 (n =3)、延迟辅助 (n =2 )和即时辅助(n =6 ) ,记录并比较 3组复苏所持续时间和成败率。分别于复苏后 5min、 6 0min和 180min监测并记录血流动力学参数。结果 无辅助、延迟辅助和即时辅助复苏持续时间分别为 (38 3± 5 8)min、 (4 3 5± 9 2 )min和 (4 8 7± 2 3 8)min ,3组比较差异无显著性 (P >0 0 5 ) ;3组成败比分别为 0 / 3、 0 / 2和 5 / 1,差异有显著性 (P <0 0 5 )。复苏成功的 5只绵羊在支持期间血流动力学逐步恢复并趋向稳定 ,血压在辅助 180min与 5min相比有明显的统计学意义 (P<0 0 5 )。结论 心跳骤停中 ,在PUCA泵即时辅助下行心脏复苏明显提高复苏成功率 ,并能恢复和稳定复苏动物的血流动力学 ;

Objective To assess the effect of the pulsatile catheter (PUCA) pump support on cardiac resuscitation in sheep,and to provide a new approach for saving cardiac arrest patients. Methods Cardiac arrest was induced by ventricular fibrillation in 11 sheep. These sheep were divided into three groups including no support (n=3), delayed support (n=2) and immediate support (n=6). Time for cardiac resuscitation and the ratio of success to failure in each group were recorded. Hemodynamic parameters including heart rate (HR), cardiac output (CO), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), central venous pressure(CVP),right ventricular end-diastolic pressure (RVEDP),left atrial pressure (LAP), and left ventricular end-diastolic pressure (LVEDP) were monitored and recorded at 5, 60 and 180 min after cardiac resuscitation with PUCA pump. Results Time for cardiac resuscitation in no support group, delayed support group and immediate support group was (38.3±5.8),(43.5±9.2) and (48.7±23.8)minutes, respectively(P>0.05),and the ratio of success to failure was 0/3,0/2 and 5/1, respectively ( P<0.05). After cardiac resuscitation with the PUCA pump support, MAP, SBP and DBP increased gradually(P<0.05).Conclusions PUCA pump can maintain the hemodynamic stability in a sheep model of cardiac arrest,and can thus increase the success rate of cardiac resuscitation. It may be suitable for resuscitating cardiac arrest patients.