摘要
1998年至2002年2月广东国际旅行卫生保健中心检出患梅毒的各类旅行人员253例(250例为潜伏梅毒)。其中男性平均年龄50.5岁(其中2人仅17岁),女性平均年龄45.5岁;男性与女性比例为1.2:1;中学以下文化程度占90%以上。253例患者的 TPPA 检查均为阳性,其中有4例 TRUST 试验阴性者。是因其配偶患梅毒,而进一步检查 TPPA 发现的。揭示 TPPA 是一种敏感、特异确认梅毒的方法。配偶间传染者31例,其首先感染方的 TPPA 的滴度高于被感染方的占83.9%。提示在夫妻之间传染者,TPPA 或可做为追溯传染途径的指标之一。本组中有239例患者接受了一个疗程的苄星青霉素治疗。其中3例有梅毒症状者,治疗2周内症状消失;有9例在治疗过程中曾出现一过性的低热。8例青霉素过敏者,接受了其它抗生素治疗。大多数病例治疗结束一周后复查 TPPA 及 RPR 或 TRUST 无明显的改变。对于公众而言,患潜伏梅毒的旅行者有更大的潜在危险性。因此加强旅行者的体检及血清学筛查,对可疑病例进一步追查,及早诊断。规范治疗是控制旅行人员梅毒传播的重要和有效的措施。
From Jan.1998 to Feb.2002,253 travelers with syphilis were found in Guangdong International Travel Healthcare Center(250 cases of the patients were latent syphilis).The male's averge age was 50.5(2 cases of them were only 17).The female's average age was 45.5.The proportion of male to female was 1.2:1.90% of them were below high school educaional level.Their results of TPPA tests were all positive and 4 cases(with TRUST negative)of them were found by further examination after their spouses were diagnosed to be syphilis patients,that indicated TPPA was a sensitive and specific diagnostic method of syphilis.What's more,there were 31 cases who were infected from their spouses and 83.9% of them had been found that the TPPA level of the persons infected earlier was higher than the level the persons infected later,that meant TPPA could be one of the index used to trace back to its route of infection.239 cases received a course of Benzathine P.G.treatment.There were 3 patients with syphilis symptoms and the symptoms disappeared within 2 weeks after the treatment.Nine patients had temporary fever during the treatment.8 cases,with an allergy to P.G.,received other antibiotic treatment.One week later after the end of treatment,the TPPA,RPR or TRUST of most cases had no significant change.To the public,the traveler with latent syphilis was a great potential risk.So,we must strengthen travelers' medical examination and blood test screening,especially to the suspects.Timely diagnosis and standardized treatment were important and effective measures to control transmittment of syphilis by the travelers.
