期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

肌肉特异性酪氨酸激酶在重症肌无力中的作用(综述) 被引量：2

下载PDF
导出
摘要 约有20%重症肌无力(MG)患者血清中检测不到乙酰胆碱受体抗体(AChRAb),称之为“血清反应阴性MG”(seronegativeMG,SNMG)。有报道71%的SNMG患者血清中存在肌肉特异性酪氨酸激酶(MuSK)抗体(MuSKAb),MuSKAb阳性SNMG患者的流行病学特征、临床特点和治疗效果与由AChRAb介导的MG(seropositiveMG,SPMG)有所不同,存在较大争议。
作者 张晓凡 徐金枝
机构地区 华中科技大学同济医学院附属同济医院神经内科
出处 《中国神经免疫学和神经病学杂志》 CAS 2005年第2期93-95,共3页 Chinese Journal of Neuroimmunology and Neurology
关键词 肌肉特异性酪氨酸激酶 重症肌无力
分类号 R746.1 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献17

  • 1Sanders DB, Andrews PI, Howard JF Jr, et al. Seronegative myasthenia gravis[J]. Neurology, 1997, 48(suppl 5):s40-s51.
  • 2Hoch W, McConville J, Helms S, et al. Auto-antibodies to the receptor tyrosine kinase MuSK in patients withmyasthenia gravis without acetylcholine receptor antibodies[J]. Nat Med, 2001, 7:365-368.
  • 3Valenzuela DM, Sitt TN, Distefano PS, et al. Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury[J]. Neuron, 1995, 15:573-584.
  • 4Burden SJ. Building the vertebrate neuromuscular synapse[J]. J Neurobiol, 2002, 53:501-511.
  • 5Liyanage Y, Hoch W, Beeson D, et al. The agrin/musclespecific kinase pathway: new targets for autoimmune and genetic disorders at the neuromuscular junction[J].Muscle Nerve, 2002, 25:4-16.
  • 6Hoch W, McConville J, Helms S, et al. Auto-antibidies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies[J]. Nat Med, 2001, 7:365-368.
  • 7Scuderi F, Marino M, Colonna L, et al. Anti-P110 autoantibidies identify a subtype of "seronegative" myastheniagravis with prominent oculobulbar involvement[J]. Lab Invest, 2002, 82:1139-1146.
  • 8Matthews I, Chen S, Smith BR, et al. Muscle-speci-fic receptor tyrosine kinase autoantibodies-a new immunoprecipitation assay[J]. Clin Chim Acta, 2004, CCA-09543:1-5.
  • 9Evoli A, Tonali PA, Padua L, et al. Clinical correlates with anti-MuSK antibodies in generalized seronegative myasthenia gravis[J]. Brain, 2003, 126:2304-2311.
  • 10McConville J, Farrugia ME, Beeson D, et al. Detection and Characterization of MuSK Antibodies in seronegative myasthenia gravis[J]. Ann Neurol, 2004, 55:580-584.

同被引文献30

  • 1胡学强,江滢.重症肌无力的免疫学和遗传学进展[J].临床内科杂志,2005,22(6):364-366. 被引量：4
  • 2[1]Maria E,Alexianu,Clifton L,et al.Advances in neuromuscular disease2003[J].J Clin Neuromus Dis,2004,4 (5):169 ～ 175
  • 3[2]Hoch W,Mc Conville J,Helms S,et al.Auto-antibodies to the tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies[J].Natl Med,2001,7:365～368
  • 4[3]Liyanagi Y,Hoch W,Beeson D.The agrin/muscle specific kinase pathway:new targets for autoimmune and genetic disorders at the neuromuscular junction[J].Muscle Nerve,2002,25:4～16
  • 5[4]Scuderi F,Marino M,Colonna L,et al.Anti-P110 autoantibodies identify a subtype of "seronegative" myasthenia gravis with prominent oculobulbar involvement[J].Lab Invest,2002,82:1139 ～ 1146
  • 6[5]Lindstrom J.Is "seronegative" MG explained by autoantibodies to MuSK?[J].Neurology,2004,62:1920～ 1921
  • 7[6]Mier AK,Havard CW.Diaphragmatic myasthenia in mother and child[J].Postgrad Med J,1985,61:725～727
  • 8[7]Burges J,Vincent A,Molenaar PC,et al.Passive transfer of seronegative myasthenia gravis to mice[J].Muscle Nerve,1994,17:1393 ～ 1400
  • 9[8]Blaes F,Beeson D,Plested CP,et al.IgG from "seronegative" myasthenia gravis patients binds to muscle cell line,TE671,but not to human acetylcholine receptor[J].Ann Neurol,2000,47:504 ～ 510
  • 10[9]Mossman S,Vincent A,Newsom-Davis J.Myasthenia gravis without acetylcholine receptor antibody:a distinct disease entity[J].Lancet 1986,1:116～118

引证文献2

二级引证文献1

中国神经免疫学和神经病学杂志
2005年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部