益肾胶囊对糖尿病大鼠胰岛素、骨密度及骨生物力学的影响

Effect of Yishen Capsule on Insulin,Bone Density and Bone Biomechanial Property in Diabetic Rats

目的研究益肾胶囊对糖尿病(DM)大鼠骨代谢的调节机制。方法四氧嘧啶腹腔注射大鼠建立糖尿病模型,予益肾胶囊、达美康+阿法迪三灌胃治疗。对照观察药物对DM大鼠胰岛素水平、骨密度、骨生物力学的影响。结果DM模型大鼠胰岛素水平、骨密度明显下降,骨生物力学显著降低。益肾胶囊治疗后有明显缓解,综合疗效优于阳性对照组。结论糖尿病大鼠存在明显骨量减少和骨质疏松。益肾胶囊对DM模型大鼠骨代谢具有多途径、多环节的有效调节作用。

Objective:To explore the regulating mechanism of Yi Shen capsule on bone metabolism of Diabetic rats models.Methods:DM rats models was established by introperitoneal injection of Alloxan.The diabetes rats were treated with condensed liquor of YS and Diamicron+Alpha D_3 respectively through tube feeding.The influence of different medicines on Insulin,bone mineral density,bone biomechanial property was observed.Results:Insulin,BMD and bone biomechanial property of the model DM rats are significantly lower than normal group.After the therapy of YS,the abnormal condition relieved markedly,and the comprehensive action of YS was better than that of positive medicine.Conclusion:These results suggested that diabetic rats had clearly osteopnia and osteoprosis.YS can modulate effectively the bone metabolism of DM rats models through many ways and many links.