短程间歇化疗方案治疗涂阳肺结核病人五年效果分析

A Clinical Study on the Short-course Intermittent Chemotherapy for the Smear-positive Pulmonary Tuberculosis cases During Five Years.

目的 评价新洲区实施短程间歇化疗方案治疗涂阳肺结核患者 5年临床效果。方法 根据项目资料实际及本次临床调查问卷 ,分析 1995年登记治愈的涂阳肺结核患者远期治疗效果。结果 2 2 1例涂阳肺结核患者 5年治愈率为 6 5 .6 % ,肺结核恶化死亡率占 15 .8% ,细菌学复发率为 10 .4 % ,放射学恶化率为11.6 % ;其中 137例全程规则治疗病人 5年治愈率为 86 .1% ,肺结核恶化死亡率占 4 .4 % ,细菌学复发率为2 .5 % ,放射学恶化率为 3.3%。结论 采取综合措施 ,全面落实直接面视下短程间歇化疗管理是彻底治愈肺结核的关键。

Objective To evaluate the clinical effect of the short-course intermittent chemotherapy for the smear-positive pulmonary tuberculosis cases in Xinzhou district,Wuhan city during five years.Methods To analyze the lang term effect on the smear-positive tuberculosis patients registered and cured in 1995 according to the project requirement and the question are of this investigation.Results Among the 221 cases of smear-positive tuberculosis, cure rate was 65 6%,mortality rate was 15 8%, the bacteriologic relapse rate was 10 4%,the focus-worsen rate was 11 6%;Among them, 137 patients were treated regularly, cure rate was 86 1%, mortality rate was 4 4%, the bacteriologic relapse rate was 2 5%,the focus-worsen rate was 3 3%.Conclusion Taking comprehensive measures and directly observed treatment short-course are the key to cure pulmonary tuberculosis-patients.