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氨基糖苷类化合物与RNA相互作用的研究进展 被引量：1

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摘要 RNA已经成为重要的药物研究靶点 ,氨基糖苷类化合物是能够与RNA作用的小分子中较有潜力的一类化合物。
作者 任博 张礼和
机构地区 北京大学药学院天然药物及仿生药物重点实验室
出处 《国外医学（药学分册）》 2004年第6期321-326,共6页 Foreign Medical Sciences(Section of Pharmarcy)
基金 国家自然科学基金资助项目 (2 0 3 3 2 0 10 )
关键词 RNA 氨基糖苷类化合物 相互作用
分类号 R346 [医药卫生—基础医学]
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参考文献15

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同被引文献16

  • 1周勤华,张毅.细菌对氨基糖苷类抗生素产生抗性的机理及其控制策略[J].中国生物工程杂志,2004,24(11):9-12. 被引量：6
  • 2何东贤,陈林,赵经伟,刘家健.氨基糖苷类化合物的研究动向——含胍基的氨基糖苷类衍生物[J].国外医药（抗生素分册）,2006,27(2):79-83. 被引量：2
  • 3Minowa N,Akiyama Y,Hiraiwa Y,et al.Synthesis and antibacterial activity of novel neamine derivatives[J].Bioorg Med Chem Lett,2006,16(24):6351.
  • 4Chittapragada M,Roberts S,Ham YW.Aminoglycosides:molecular Insights on the recognitionof RNA and aminoglycoside mimics[J].Perspect Medicin Chem,2009,28(3):321.
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  • 6Paul DJ,Seedhouse SJ,Disney MD.Two-dimensional combinatorial screening and the RNA Privileged Space Predictor program efficiently identify aminoglycoside-RNA hairpin loop interactions[J].Nucl Acids Res,2009,37:5894.
  • 7Doi Y Wachino Jun-ichi,Yamane K,et al.Spread of novel aminogly-coside resistance gene aac(6')-Iad among acinetobacter clinical isolates in Japan[J].Antimicrob Agents Chemother,2004,48(6):2075.
  • 8Chen J,Yang L,Yang A,et al.Maternally inherited aminoglycosideinduced and nonsyndromic heating loss is associated with the 12SrRNA C1494T mutation in three Han Chinese pedigrees[J].Gene,2007:4.
  • 9Eva w,Alex V,Yasutaka M,et al.Crystal structure of a GCN5-related N-acety ltransferase:serratia marcescens aminoglycoside 3-N-acetyltransferase[J].Cell,1998(94):439.
  • 10Riccio ML,Docquier JD,Amico ED,et al.Novel 3-N-aminoglycoside acetyltransferase gene,aac(3')-Ic,from a Pseudomonas aeruginosa Integron[J].Antimicrob Agents Chemother,2003:1746.

引证文献1

国外医学（药学分册）
2004年 第6期

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