重庆部分地区HDV感染的调查

INVESTIGATION OF HDV INFECTION IN SOME AREAS OF CHONGQING

本文收集了重庆部分地区乙肝患者ＨＢｓＡｇ无症状携带者血清标本２４２份，用ＥＬＩＳＡ法检测抗－ＨＤ，２４份阳性，阳性率为９．９１％，与其它地区比较重庆部分地区ＨＤＶ感染率较高，且郊区的阳性率明显高于市区，此结果符合以前曾报告的ＨＤＶ在我国呈地方性分布的论述。原发性肝癌病人，急、慢乙型肝炎病人和ＨＢｓＡｇ无症状携带者中，以原发性肝癌病人抗－ＨＤ阳性率较高，提示ＨＤＶ感染可能与原发性肝癌的致病有关。

serum samples from HBsAg positive individuals were collected for anti-HD assay by ELISA. 24 samples (9. 91%)were positive. Furthermore, the rate in rural areas was higher than in districts,which coincided with the characteristics of the previously described epidemiological features of FDV infection in China.The anti-HD positive rates were different among patients with primary hepatocarcinoma (PHC), acute and chronic viral hepatitis, and HBV carriers. The higher rate among cases suggested that HDV infection might be correlate with the pathogenesis of PHC.