摘要
将１４０名冠心病人随机分为四组，按规定使用小剂量阿斯匹林及硝苯吡啶，经观察发现：Ｔ＿ｘＢ＿２／ＰＧＦ比值为对照组＞ＡＳＡ组＞ＮｉＦ组＞Ｍ组；用药后ＮｉＦ、Ｍ组ＰＡＷＰ较前明显降低，Ｃｉ、Ｃｏ、Ｆｓ有所增加．结果提示治疗量的ＮｉＦ与小剂量ＡＳＡ合用对ＴｘＡ２／ＰＧＩ２平衡、改善心功能效应最佳。
140 patients with coronary artery disease (CAD) were divided randomly into fourgroups. According to the project,nifedipine and low dose aspirin were given respectively. Thecurrent study indicated that the order of the TXA2/PGI_2 ratio of the different groups was asfollows: control group>ASA group>NIF group>ASA+NIF group. After treatments, PAWP inpatients of NIF and ASA+NIF group decreased but Ci, Co and Fs increased. This suggestedthat NIF plus low dose aspirin had significant effects on regulating TXA_2/PGI_2 and improvingheart function.
关键词
冠心病
硝苯吡啶
阿斯匹林
血栓素
Coronary artery disease. Nifedipine Aspirin TXA_2 PGI_2
