血清胆汁酸临床参考值范围研究及在职业性肝病中的应用

AN INVESTIGATION ON CLINICAL REFERENCE VALUE OF SERUM BILE REFERENCE VALUE AND ITS APPLICATLON IN OCCUPATIONAL LIVER DISEASE

外周循环血中胆汁酸的升高和其他肝功能试验及肝脏的组织变化相吻合，且比常规肝功试验灵敏得多。故在常规肝功试验不能检出任何异常时，血清胆汁酸测定具有重要的早期诊断价值，同时可作为职业性肝病的敏感监测指标。用气相色谱法对７０例健康者血清胆汁酸进行了测定，结果表明：四种血清胆汁酸按男女性别分组均无显著性差异，胆酸（ＣＡ）与鹅脱氧胆酸（ＣＤＣＡ）无年龄组差别（Ｐ＞０．０５）；而石胆酸（ＬＣＡ）和脱氧胆酸（ＤＣＡ）合并年龄组后以３０岁为界分为两组，其结果有显著性差异（Ｐ＜０．０５）。由此初步提出血清胆汁酸的９０％多元临床参考值范围。

The result of serum bile acids (SBA) in the peripheral circulation is consistent with some other liver function tests and with hepatic histological alterations. It is far more sensitive than routine liver function tests. The SBA plays an important role in the early-stage diagnosis when conventional tests give no abnormal signals, and they can be also used as a sensitive monitor and/or indicator of occupational hepatitis. The SBA of 70 healthy persons were measured by gas chromatography after being derived with heptafluorobutyric anhydride (HFBA). No statistical differences by sex were found for four kinds of SBA, and also among various age groups for cholic acid (CA) and chenodexycholic acid (CDCA) (P>0.05). However, Lithocholic acid (LCA) and deoxycholic acid (CDA) differed significantly (P<0.05) for patients above and below age 30. Thus, the authors put forward a preliminary clinical reference value range of SBA.