嗜好因素与肝癌关系的流行病学研究

AN EPEDEMIOLOGICAL STUDY ON THE RELATIONSHIP AMONG TOBACCO SMOKING, ALCOHOL DRINKING, GREEN TEA AND HEPATOCELLULAR CARCINOMA (HCC).

本文通过对烟、酒、茶等嗜好因素与肝癌死亡率的相关分析和病例对照多元条件Ｌｏｇｉｓｔｉｃ回归分析，显示饮茶率与肝癌、消化道癌有极显著的负相关，相关系数分别为－０．９８和－０．９２，饮酒率与之存在一定程度的正相关。启东肝癌重要的危险因素除ＨＢＶ感染外，饮酒因素亦是危险因素之一，其ＯＲ值达３．４７；而饮茶可能为一保护因素。上述结果经多元模型拟合，认为是比较可信的。

Using Correlative analysis and case-control study methods, we researched the etiologic relationship among tobacco smoking,alcohol drinking,green tea and HCC. The results showed that the rate of drinking green tea was significantly negative relation with that of HCC and other digestive cancers. The correlation coefficient were-0. 98and- 0. 92 respectively. The rate of drinking alcohol was positive relation with the rate of HCC and other digestive cancers. Multivariate logistic analysis of case-control showed that the most important agent of HCC (besides HBV infection) was alcohol drinking (including the history of drinking alcohol,beginning age younger than 16 yre,)in Qidong. The OR value of HBV infection and alcohol drinking were 5. 45 and 3. 47 respectively. Drinking green tea was the only protective agent. At the other hand,the two models established were both in goodness-of-fit,which meant that the conclusions discussed in former were credible.