摘要
目的 探讨膀胱移行细胞癌中转化生长因子β的Ⅰ、Ⅱ型受体(TGFβ-R-Ⅰ、TGFβ-R-Ⅱ)表达及其意义。方法 采用免疫组化技术(SABC法)对72例膀胱癌,14例正常膀胱组织TGF β-R-Ⅰ、R-Ⅱ进行检测,结合临床资料进行分析。结果 TGFβ-R-Ⅱ在膀胱癌组及正常膀胱组织中均表达:TGFβ-R-Ⅰ在膀胱癌中阳性率较正常膀胱组织阳性率低(P<0.01),TGFβ-R-Ⅰ在高分级膀胱癌中表达阳性率较低分级膀胱癌低(P<0.01);在复发癌的阳性表达率较初发性癌的阳性率低(P<0.01)。结论 TGF β1对膀胱癌是一种重要负性调节因子,可抑制膀胱癌进展,TGFβ-R-Ⅰ缺失使TGFβ系统完整性受到破坏,TGFβ1失去负性调节作用,TGFβ-R-Ⅰ表达可做为判断膀胱癌预后的指标之一。
Objective To study the expression of TGFβ receptor Ⅰ,Ⅱ (TGFβ-R-Ⅰ,R Ⅰ)and their effect on human transitional cell carcinomas. Methods 72 specimens of human transitional cell carcionmas (TCCs)and 14 normal bladders as control were assessed by immumohistochemical method(SABC method). Results TGFβ-R-Ⅰ in TCCs was lower than that in normal bladders(p<0.01). The positive rates of TGF β1 - R- 1 were significantly lower in poorly differentiated TCCs(p<0.01)and correlate with the recurrencc(p< 0.01).Conclusions TGFβ1 can act as a negative regulating factor and inhibit the growth of TCCs,the defect of TGFβ- R - Ⅰ breaks the functional intactness of TGFβ1 signal transduction pathway and causes the functional loss of negative regulation of TGKβ1 that advances the progress of transitional cell carcinoma.
出处
《现代泌尿外科杂志》
CAS
2001年第1期11-13,30,共4页
Journal of Modern Urology