中国人5,10-亚甲基四氢叶酸还原酶基因多态性与冠心病、神经管畸形易感性关系的Meta分析

Meta Analysis on Relationship between MTHFR Gene Polymorphism and Susceptibility of Coronary Heart Disease and Neural Tube Defects in Chinese Population

目的了解我国人群5,10-亚甲基四氢叶酸还原酶(MTHFR)基因多态性与冠心病、子代神经管畸形发生的关联性。方法在全面文献回顾的基础上对各研究OR值进行Meta分析。结果共有13篇符合条件的文献纳入分析,其中冠心病9篇,神经管畸形4篇。Meta分析表明,以CC基因型为参照,携带TT、CT基因型的个体发生冠心病的OR值分别为2.35和1.31;父母携带TT、CT基因型,子代发生神经管畸形OR值分别为3.13和1.66。携带至少,个T等位基因的个体发生冠心病、子代神经管畸形的OR值分别为1.72和1.94。结论MTHFR基因多态性与我国人群冠心病、子代神经管畸形的易感性密切相关。

Objective To explore the relationship between MTHFR gene polymorphism and susceptibility of coronary heart disease and offspring's neural tube defects among Chinese population. Methods The related literatures with same topic and similar methods concerning Chinese population were reviewed; the OR values in those studies were incorporated by Meta analysis to assess the disease susceptibility with MTHFR mutation genotype. Results 13 papers (9 for coronary heart disease and 4 for neural tube defects) together were selected based on the criteria. Meta analysis results showed that the combined OR values of coronary heart disease for subjects with TT and CT genotypes were 2.35 and 1.31, respectively. Relative risk of neural tube defects for offspring with parental TT and CT genotypes were 3.13 and 1.66. OR values of coronary heart disease and neural tube defects for subjects with at least one T allele were 1.72 and 1.94, respectively. Conclusions The results suggested that MTHFR gene polymorphism was significantly associated with susceptibility of coronary heart defects and offspring's neural tube defects in Chinese population.