硝酸氧化法合成对叔丁基苯甲酸

Synthesis of p-tert-butylbenzoic acid by oxidizing with nitric acid

报道了以硝酸为氧化剂 ,把对叔丁基甲苯氧化成对叔丁基苯甲酸的新方法。在初步实验的基础上 ,对硝酸浓度、反应温度、反应时间等因素进行了正交实验 ,找到了反应的最佳条件。该方法工艺简单可行 ,成本较已有生产方法降低 ,适合于工业化生产。

In this article,the synthesis of p-tert-butylbenzoic acid by using nitric acid as the oxidizing agent was introduced.The raw material was p-tert-butyltoluene.Three kinds of conditions which affected the reaction were discussed:The concentration of nitric acid,the temperature and time of the reaction.The best condition was also found by way of orthogonal experimental design.This simple synthetic route was appropriate for industrial production.