血清中氨基酸含量对急性缺血性脑血管病诊断的探讨

Diagnostic implication of measurement of amino acid in serum of AICVD patients

目的 探讨血清中氨基酸的含量变化与短暂性脑缺血和脑梗死体积大小的关系以及对急性缺血性脑血管病的超早期诊断的意义。方法选择发病6h以内的急性缺血性脑血管病(AICVD)患者80例,其中脑梗死(CI)组57例,短暂性脑缺血(TIA)组23例,CI组中大体积梗死19例,中体积梗死22例,小体积梗死16例,各取血清进行高效液相色谱法分析测定血清Glu和GABA。结果TIA组的超早期血清中L-Glu、GABA含量高于对照组,低于CI组;CI组超早期血清中L-Glu、GABA含量高于对照组和TIA组;超早期梗死灶体积大小与血清中L-Glu、GABA含量呈正相关,含量越高,梗死灶体积越大。结论患者血清中L-Glu、GABA含量高低,对急性缺血性脑血管病的超早期诊断有一定的临床价值。

Objective To investigate the changes of amino acid level in sera and its relationship with transient ischemic cerebral infarction and affected size of infarction,to discuss its implication in the most early diagnose in AICVD. Methods 80 AICVD attacked in 6 hours were divided into CI group(57 cases) and TIA group(23 cases). In CI group the infected size of big, middle and small volume was 19,22 and 1 cases respectively. Sera were collected and amino acids were measured by HPLC. Results L-Glu , GABA were higher in the most early stage of TIA than the control group and TIA group,lower than that in CI group. The affected size in the most early stage were positively correlated to L-Glu and GABA level in sera. Conclusions The sera level of L-Glu and GABA is of diagnostic value in the most early stage of AICVD.