牡荆子提取液对鼠血脂、肝脂和血糖的调节作用

Regulation of Negundo Chastetree extract liquor on blood-fat, liver-fat and blood-sugar in rat and mouse

目的为探讨牡荆子提取液对心血管系统的药理作用机制,初步观察了牡荆子提取液对大小鼠血脂、肝脂和血糖的影响。方法采用牡荆子提取液每日按5.0、7.5、10.0mL·kg-1·b.w.分别灌胃。结果结果发现,能使小鼠高脂饲料所致的血脂和肝脂水平下降(P<0.05);同时,也能使正常鼠肝中甘油三酯蓄积程度降低。结论结果提示牡荆子具有一定的降血脂和护肝作用;还有促进小鼠肝糖原生成作用。

AIM: To investigate pharmacdogical mechanism of Negundo Chastetree extract liquor (NCEL), the effect of (NCEL) on blood-fat, liver-fat and blood-sugar in the rat and the mouse were studied in this paper. METHODS: The experimental models were established by giving rats and mice NCEL orally at dosages 5.0, 7.5, 10.0 mL/kg.b.w respectively. Then the level of blood-fat, liver-fat, and blood-sugar were observed. RESULTS: The level of serum triglyceride and total cholesterol decreased considerably in mice, at the same time, the increase of triglyceride induced by high lipid diet in liver of mice were inhibited significantly. In addition, the level of fatty liver of hepatic homogenization triglyceride in rats with induced by DL-ethionine was lowered obviously by oral administration of NCEL. CONCLUSION: These results suggest that NCEL may have effects of reducing blood-fat and pretecting liver.