摘要
目的 探讨人类白细胞抗原(HLA) DRB1基因频率与乙型肝炎病毒感染的相关性。方法 用聚合酶 链反应/序列特异性引物法对兰州地区汉族健康者48例、慢性乙型肝炎患者53例和急性乙型肝炎感染者21例进行 HLA DRB1等位基因分型,并作相关性分析。结果 兰州地区慢性乙型肝炎组HLA DRB1 07X的频率明显高于健 康对照组和急性自限性感染组(P<0.05)。结论 HLA DRB1 07X可能与兰州地区汉族慢性乙型肝炎感染相关, 免疫遗传因素参与慢性乙型肝炎的发病机制。
Objective To investigate the frequency of different genotypes of human leukocyte antigen-DRB1(HLA-DRB1) gene and their relations to hepatitis B virus(HBV) infection in Lanzhou district of China. Methods HLA-DRB1 alleles in 53 patients with chronic hepatitis B,21 patients with acute hepatitis B,and 48 normal control subjects were analyzed using the polymerase chain reaction/sequence specific primer (PCR/SSP) technique. The association between HBV infection and above gene polymorphisms was analyzed by Chi-quare test. Results The frequency of HLA- DRB1*07X allele in the chronic hepatitis B group was markedly higher than that in the normal control group, and the acute hepatitis B group(P< 0.05). Conclusion HLA- DRB1*07X is closely related with susceptibility to chronic hepatitis B of the Han Nationality in Lanzhou district. This outcome suggests that host HLA class Ⅱ allele may be an important factor participating in the pathogenesis of chronic hepatitis B.
出处
《临床荟萃》
CAS
北大核心
2005年第6期307-309,共3页
Clinical Focus
