不同海拔地区健康人群血清白细胞介素和C-反应蛋白水平的初探

Serum interleukins and C-reactive protein in humans of different high altitudes

目的 探讨高原低氧以及强紫外线等环境因素是否对血清白细胞介素(IL)和C 反应蛋白(CRP)产生影 响。方法 采用竟争性放射免疫法及免疫比浊法,测定53例格尔木地区(海拔2806m)和50例雁石坪地区(海拔 4800m)青藏铁路健康筑路男性工人,血清IL和CRP水平。结果 高海拔地区(雁石坪组)与中度海拔地区(格尔木 组)相比,血清IL 6含量和CRP显著增高(P<0.01),高海拔组IL 1和IL 8的含量高于中度海拔组(P<0.05),血 清IL 2无明显变化(P>0.05)。结论 血清IL 1、IL 6、IL 8和CRP水平在高海拔地区显著增高,这一结果提示环 境因素(氧化应激、强紫外线)可能诱导炎症反应的发生。

Objective Hypoxia and ultraviolet are known to induce an inflammatory response in immune cells and endothelial cells. To investigate whether hypoxia and ultraviolet irradiation (UV) as well as other environmental factors at the different high altitudes effect on interleukins (IL) and C-reactive protein (CRP). Methods With competitive radio-assay and immune turbidity method, IL and CRP were measured in 53 healthy male workers at high altitude of 2 806 m in Ge Ermu area and 50 healthy male workers at high altitude of 4 800 m in Yian Shipin area, which both participated in building Qinghai-Tibetau railroad. Results Serum IL-6 and CRP showed significant increase when compared between high altitude area (Yianshipin group) and moderate altitude (Ge-ermu group)(P< 0.01). IL-1 and IL-8 concentrations were higher in high altitude group than in moderate altitude group(P< 0.05). Serum IL-2 remained no significant difference(P> 0.05). Conclusion Serum IL-1,IL-6, IL-8 and CRP concentrations increased significantly, and the results suggest serious environment factors(oxidation stress, strong UV) might be involved in the inflammatory reaction.