健脾活血中药联合化疗治疗大肠癌术后患者的疗效观察

Observation on Therapeutic Effect of Jianpi Huoxue Herbs Combined with Chemotherapy in Treating Post-operational Colonic Cancer Patients

目的观察健脾活血中药 (简称中药 )联合化疗对大肠癌术后脾虚证患者的疗效。方法采用随机对照研究方法将 6 4例患者分为两组 ,治疗组 (43例 )用中药加化疗治疗 ,对照组 (2 1例 )单用化疗治疗 ,两组疗程均为 3个月。观察两组患者的疗效、脾虚症状的改善以及不良反应的发生情况。结果治疗组和对照组的肿瘤缓解率分别为 39.5 %和 33.3% ;中医脾虚证候疗效 :控显率治疗组 (72 .1% )与对照组 (19 0 % )比较 ,差异有显著性 (P <0 .0 1)。治疗组的不良反应发生率低于对照组 (P <0 .0 5 )。结论健脾活血中药联合化疗对改善大肠癌术后患者脾虚症状 。

observe and compare the therapeutic effect of Jianpi Huoxue herbs (JPHXH) combined with chemotherapy (CT)in treating post-operational colonic cancer patients with Pi deficiency Syndrome (PDS). MethodsAdopting randomized control trial method, 64 patients were divided into two groups. The treated group (n=43) received JPHXH plus CT and the control group (n=21) received CT alone. A treatment course of 3 months was applied to both groups. Therapeutic effect, changes of PDS and incidence of adverse reaction in the two groups were observed. ResultsThe tumor remission rate in the treated group and the control group was 39.5% and 33.3%, respectively. The effective rate on PDS in the treated group and the control group was 72.1% and 19.0%, respectively, showing significant difference (P<0.01). The incidence of adverse reaction was lower in the treated group than that in the control group (P<0.05). ConclusionJPHXH is effective in treating post-operational colonic cancer patients with PDS and relieving the adverse reaction of chemotherapy to certain extent.