中药神农33号注射液配合西药治疗多器官功能障碍综合征患者的临床观察

Clinical Observation on Treatment of Multiple Organ Dysfunction Syndrome with Auxiliary Treatment of Shennong No.33

目的配合使用中药神农 33号注射液 (简称神农 33号 )对多器官功能障碍综合征 (MODS)患者进行治疗 ,以急性生理与慢性健康评估 (APACHEⅡ、Ⅲ )评分作为指标进行疗效观察。方法将 12 9例MODS患者随机分为治疗组 (72例 )及对照组 (5 7例 )。两组均用西医综合治疗 ,治疗组同时配合使用中药神农 33号 (静脉滴注 ,连用 7天 ) ,观察两组患者入院后 2 4h内、第 3、5、7天的APACHEⅡ、Ⅲ评分变化趋势及血清内毒素水平。结果治疗组患者存活 5 0例 ,死亡 2 2例 ;对照组患者存活 2 5例 ,死亡 32例。死亡患者APACHEⅡ、Ⅲ评分均高于存活患者 (P <0 .0 5 )。治疗组患者APACHEⅡ、Ⅲ评分第 5、7天均低于对照组 (P <0.0 5 ) ,内毒素水平第 3、5、7天均低于对照组 (P <0 .0 5 )。结论MODS患者经加用中药神农 33号治疗后病情得到改善 ,APACHE评分下降。APACHE评分系统可以作为判断危重病患者病情及预后的指标 ,且以APACHEⅢ评分更确切目的配合使用中药神农 33号注射液 (简称神农 33号 )对多器官功能障碍综合征 (MODS)患者进行治疗 ,以急性生理与慢性健康评估 (APACHEⅡ、Ⅲ )评分作为指标进行疗效观察。方法将 12 9例MODS患者随机分为治疗组 (72例 )及对照组 (5 7例 )。两组均用西医综合治疗 。

observe the therapeutic effect of Shennong No.33 (SN33) in treating multiple organ dysfunction syndrome (MODS) by APACHE Ⅱ and APACHEⅢ scoring. MethodsOne hundred and twenty-nine patients of MODS were randomly divided into the treated group (n=72) and the control group (n=57), they were treated with comprehensive therapy and to the treated group, SN33 was given additionally. The changes of APACHEⅡ and APACHEⅢ scores and blood endotoxin level were observed at the time points of within 24 hrs after hospitalization, and the 3rd, 5th and 7th day. ResultsIn the treated group, 50 patients survived and 22 died, while in the control group, 25 survived and 32 died. The APACHEⅡ and APACHEⅢ scores of the survivors were higher than those of the decedent (P<0.05), which in the treated group was lower than those in the control group (P<0.05). The blood level of endotoxin in the treated group was also lower than that in the control group (P<0.05). ConclusionSN33 in treating MODS could improve patients' condition, lead to the lowering of APACHE scores. APACHE scoring system could be applied as the criteria for evaluating the condition and prognosis of critical patients, and the APACHEⅢ scoring is more accurate.