均匀设计在中医药研究中的应用

Application of Uniform Design in Research of Traditional Chinese Medicine

均匀设计将试验有关因素的各水平数均匀分散在实验范围内 ,使每一个试验点都有更好的代表性 ,减少了实验次数 ,且实验结果可用计算机处理 ,在寻找最佳实验条件、最佳配比等方面是选择优化条件的有力工具 ,因而大量运用于中药制剂的提取工艺、成型工艺的研究。近年来将其引入研究方剂和药物配伍。研究显示 :对一些传统方剂的配伍分析结果与均匀设计的分析结果一致。均匀设计方法可作为一种筛选研究手段 ,用于中药的现代化研究 ;运用均匀设计方法对经方进行研究 ,把其所对应的“证”作为考察指标 ,有助于深入认识“方证”的科学内涵。

In the uniform design, all level number of experimental relevant factors are equally distributed in the range of experiment, each experimental point shows representation better. The times of experiment are reduced and the data obtained can be treated with computer. Uniform design is a potent tool in seeking for the optimal experimental condition or the optimal proportion of experiments. So, it is often used to study extraction and preparation form technology of TCM. In recent years, the uniform design has been used in the domain of traditional Chinese recipe and the compatibility of its component drugs. The study showed that the analytical results of TCM theory and that of uniform design are extremely consistent. As an optimal screening means in modernizing study on Chinese herbs, using uniform design in studying classical recipe, the 'syndrome' corresponding recipe whereas it is helpful to deeply recognize the scientific connotation of 'recipe syndrome'.