新疆汉族和维吾尔族胆汁中结合胆汁酸含量与胆固醇类结石形成关系的探讨

Investigation of The Relationship between Conjugated Bile Acid Contents in Bile and Formation of Cholesterol Gallstone in Different Nationalities in Xinjiang

作者用高效液相色谱法（ＨＰＬＣ）对３３例汉族和维吾尔族胆固醇结石患者和２２例正常人胆汁的８种结合胆汁酸进行了测定，旨在探讨汉族、维吾尔族两民族间胆汁酸含量及构成的差异，揭示胆汁酸与胆固醇结石形成的关系。结果表明：（１）汉族和维吾尔族正常人胆囊胆汁总胆酸分别为１１２．４３ｍｇ／ｍｌ和９４．２７ｍｇ／ｍｌ，明显高于瑞典正常人，与国内资料相同，两民族间差别不明显。（２）两民族正常人胆囊胆汁各种结合胆汁酸含量、构成比和比值间存在差别。汉族鸽脱氧胆酸（ＣＤＣＡ）含量明显高于维吾尔族，脱氧胆酸（ＤＣＡ）含量明显低于维吾尔族。我们认为造成差别的原因可能是两民族膳食成分不同，提示维吾尔族正常人可能较汉族正常人易发生结石。（３）胆石患者胆囊胆汁总胆汁酸低于正常组，胆汁酸构成比在两组间无明显差别，说明结石患者胆汁酸组分为均衡减少。胆汁酸含量减少，使对胆固醇的溶解能力下降，易形成结石。

This paper reports the use of high pressure liquid chromatography to the analysis of eight conju-gated bile acids in 22 normal biles and 33 biles of patients with cholecterol gallstone between the Hanand Uygur in Xinjiang. The results were as follows:(1)The total bile acids of normal gallbladder bilein Han and Uygur nationality were 112. 43 mg/ml and 94. 24 mg/ml, respectively, which was higherthan that of the normal Swedish and similar to the domestic data。No distinct difference was shown be-tween the Han and Uygur nationality。(2)The content,percentage proportion and ratio of conjugatedbile acids in normal gallbladder bile differed greatly between the Han and Uygur.The content of CD-CA in Han group was higher than that of Uygur and DCA lower than that of the latter,the differenceswere significant statistically. We considered that the reason may be due to a variety of compositions intheir diets,which suggested that the normal Uygur subjects are prone to develope cholesterol gallstonecompared to the normal Han.(3 ) The total bile acid of gallstone group was lower than that normalone, No significant difference in percentage proportions of bile acids was found between the twogroups,suggesting that the decrease of bile acids in gallstone patients was proportional.The decreaseof bile acids may lower the capacity of cholesterol dissolved in bile,which results in the formation ofgallstone。