摘要
目的探讨胃癌细胞卵巢远处转移的生物学特征及其临床意义。方法应用免疫组化方法,分别检测19例胃癌卵巢转移标本雌激素受体CD44V6,并以10例胃癌肝脏转移病例作为对照组进行分析比较。结果肝脏转移组胃癌组织和肝脏组织的ER阳性率分别为10%和20%,卵巢转移组胃癌组织和卵巢转移组织ER阳性率分别为47.4%和73.8%,两组差异有显著性(P<0.01);肝脏转移组胃癌组织和肝脏组织的CD44V6阳性率分别为70%和60%,卵巢转移组胃癌组织和卵巢转移组织CD44V6阳性率分别为63.2%和42.1%,两组差异无显著性(P>0.05)。结论CD44V6在胃癌的卵巢转移中作用无明显相关性。胃癌雌激素受体阳性率的卵巢转移癌受体阳性率呈正相关,具有ER活性的胃癌细胞,通过E2-ER的结合,导致胃癌细胞向卵巢转移。
Objective To investigate the biology character of ovarian met astasis in gastric cancer. Method 19 cases of gastric cancer with ovarian me tastasis were detected for estrogen receptor and CD44V6 by immnohistochemistry methods. and 10 cases of gastric cancer with hepatic metastasis as control. R esults In 19 gastric cancer with hepatic metastasis tissue, the postive rate of estrogen receptor in the gastric and ovarian tissues were 47.4 % and 73.8%, In the control group, the postive rate of estrogen receptor in the gastric and hepatic tissues were 10% and 20%,the two groups has obvious difference(P<0.01); In the experimental group, the postive rate of CD44V6 in the gastric and ovaria n tissues were 63.2% and 42.1%, In the control group, the postive rate of CD44V6 in the gastric and hepatic tissues were 70% and 60%, the two groups has no obv ious difference(P>0.05). Conclusion There are the positive correlation betwe en ovarian metastasis in gastric cancer and estrogen receptor; Ovarian metastas es in gastric cancer occur by E2-ER combination. The gasric cell metastasizs to the ovarian tissue by E2-ER combination.
出处
《中国医学工程》
2005年第1期38-39,共2页
China Medical Engineering
