胃肠道小细胞癌诊治体会(附5例报告)

Diagnosis and treatment of gastrointestinal tract small-cell carcinoma

目的探讨胃肠道小细胞癌的诊断、治疗,提高对胃肠道小细胞癌的认识.方法总结我院收治的5例胃肠道小细胞癌的临床资料.结果本组患者中,男2例,女3例,平均年龄为54岁(25～70岁).肿瘤位于胃3例,升结肠1例,直肠1例.4例患者行手术治疗,其中2例给与化疗(或和放疗).全部病人中,1例病人发现肝转移,1例发现脑转移,1例同时伴有肝和脑转移.生存期最短20d,最长16个月,中位生存期5.5个月.结论手术联合化疗有助于改善胃肠道小细胞癌的预后.

Objective To sum up our experience on the diagnosis and treatm ent of the gastrointestinal tract small-cell carcinoma(GI SCC). Methods Cli nical data of 5 GI SCC cases admitted during the past 50 years in Tianjin Cancer Hospital were analyzed retrospecifitively. Results Median age was 54 years. Three tumors were located in the stomach and one in accending colon and one in rectum. Operation was performed on 4 patients, including two received chemothera py (or with radiotherapy). One patient had liver metastases, another had brain m etastases, 1 patient had brain and liver metastases simultaneously. Survival is in the range of 20 days to 16 months, median survival 5.5 months. Conclusions gastrointestinal tract small-cell carcinoma is a very rare aggressive malign ancy ,with early metastatic spread and a dismal prognosis, surgery combined chem otherapy should be recommended.