血浆中分子物质在大鼠感染性休克发病中的作用

The Role of Moderate-mass Molecules of Piasma in Septic Shock of Rat

本实验在大白鼠腹膜炎性感染性休克的模型上，研究了血浆中分子物质和肠道吸附剂的作用，并从溶酶体膜及自由基变化方面对其作用机制进行了探讨。实验结果表明：血浆中分子物质含量变化在休克组中比反映自由基水平的血浆丙二醛（ＭＤＡ）含量变化出现早，能反映内源性中毒时的时相和严重程度。中分子物质可能是通过损害溶酶体膜而起作用的。

Excrementitious suspension was injected into the peritonaetim of rats to establish an experimentalmodel of septic shock.We observed the role of moderate-mass molecules and enterosorbent and in themeantime,studied their functional mechanisms from changes of lysosomease and free radical.The results suggested that the change of moderate一mass molecules in the seplic shock was earlierthan plasma MDA. It could reflect the time phase and serious degree of endogenous intoxication,Therole of moderate一mass molecules of plasma could be through injuring the membrane of lysosome. Thefact by using enterosorbent and 654-2 increasing the level of SOD and GSH一px,indicated that theyhad a protective effect in the septic shock.