血清残粒脂蛋白胆固醇水平与2型糖尿病动脉粥样硬化的关系

The relationship between serum remnant lipoprotein cholesterol and atherosclerosis in patients with type2diabetes mellitus

目的探讨血清残粒脂蛋白胆固醇(RLP-C)在2型糖尿病动脉粥样硬化发生、发展中的作用及其相关性。方法用免疫分离法测定99例2型糖尿病病人(其中有动脉粥样硬化51例,无动脉粥样硬化48例)及40例正常对照组血清RLP-C水平。结果99例2型DM病人的血清RLP-C水平比40例正常对照显著增加[(0 31±0 19)mmol/L vs(0.19±0.12)mmol/L,P<0 01]。糖尿病组中有动脉粥样硬化的血清RLP-C(0.41±0.23)mmol/L水平显著高于无动脉粥样硬化者的血清RLP-C(0.25±0.16) mmol/L水平(P<0 01)。2型糖尿病病人血清RLP-C水平与TG、VLDL-C成正相关。结论2型糖尿病动脉粥样硬化的发生与RLP-C水平增加有密切联系,RLP代谢异常可能是2型糖尿病发生动脉粥样硬化的重要危险因素之一。

Objective:To investigate the effect of serum remnant lipoprotein cholesterol(RLP-C)in the occurrence and development of atherosclerosis(AS)of type2diabetes mellitus(DM)and their correlation.Methods:Serum RLP-C level was assayed by using immunoseparation method in99patients with type2diabetes mellitus(51with atherosclerosis,48without atherosclerosis)and in40controls.Results:Serum RLP-C level in99patients with type2DMwas significanttly increased than that in40controls[(0.31±0.19)mg/L vs(0.19±0.12)mmol/L,P<0.01].Among type2DMpatients,serum RLP-C[(0.41±0.23)mmol/L]in type2diabetes mellitus with atherosclerosis was significantly higher than that[(0.25±0.16)mmol/L]in type2diabetes mellitus without atherosclerosis(P<0.01).Linear correlation analysis showed that serum RLP-C concentration was positively correlated with TG and VLDL-C in patients with type2diabetes mellitus.Conclusion:Diabetic atherosclerosis is closely related to the increase of serum RLP-C level.The abnormality of RLP metabolization is a critical factor for diabetic atherosclerosis.