脑梗死患者长程服用尼膜同的近期与远期疗效研究

Study on the Short-term and Long-term Efficacy of Taking Nimotop for Longer time to Treat Patients with Cerebral Infarction

【目的】探讨尼膜同长程给药治疗脑梗死和预防其复发的效果及其机制。【方法】119 例脑梗死患者随机分为防治组59例,对照组 60 例。两组常规治疗相同,防治组在常规治疗的基础上给尼膜同每次 30mg,每天3次,至少6个月以上。观察两组治疗1个月的临床疗效和1年内的复发率,并于治疗前和治疗后1年,分别进行血液流变学、血脂和血小板聚集率检查。【结果】防治组治疗 1 个月的显效率为 78.0%,总有效率为98.3%,明显高于对照组的54.3%和71.1%(均P<0.01);1年内的复发率为6.78%,明显低于对照组的23.33%(P<0.01)。与脑梗死复发有关的血黏度、血脂、纤维蛋白原及血小板聚集率等指标防治组也明显低于对照组(均P<0.01)。【结论】尼膜同长程给药不仅可提高疗效而且可有效预防脑梗死复发,其机制可能与其降低血脂、抑制血小板聚集和改善血液流变学指标有关。

To explore the effect and mechanism of taking nimotop for longer time in treating and preventing the reattack of cerebral infarction.One hundred and nineteen patients with cerebral infarction were divided randomly into treatment group (59 cases) and control group (60 cases) .The basic treatment in the two groups was the same . The treatment group took nimotop 30mg, three times a day,for at least 6 months.The clinical effect in 1 month and the rate of reattack in 1 year were observed. The two groups were measured on hemorrheology, blood lipid and platelet aggregation rate before treatment and one year after treatment.One month after treatment, the significant effective rate in nimotop treatment group was 78.0% ,the total effective rate was 98.3% ,but in the control group it was 54.3% and 71.1%respectively (all P<0.01);the rate of reattack in one year was 6.78% in the treatment group ,23.33% in the control group(P<0.01). The blood viscosity ,blood lipid, fibrin and the platelet aggregation rate relating to reattack of cerebral infarction were lower significantly in the treatment group than in the control group (all P<0.01).[Conclusion]Taking nimotop for longer time may increase the effect and prevent the reattack of cerebral infarction.The machenism may be related to decreasing blood lipid, anti-platelet aggregation and improving hemorrheology.