输卵管性不孕妇女输卵管沙眼衣原体感染与血清IFN-γ的关系

Relationship Between the Infection of Chlamydia Trachomatis in Tubal Infertility and Serum Levels of IFN-γ

【目的】研究输卵管沙眼衣原体感染导致的输卵管不孕与患者血清γ干扰素(IFN -γ)水平的关系。【方法】应用荧光定量 PCR法检测 51 例输卵管不孕妇女输卵管液沙眼衣原体感染情况,并同时检测血清IFN -γ。【结果】51例输卵管不孕妇女输卵管液沙眼衣原体阳性 39 例(76.5%),阴性 12 例(23.5%);沙眼衣原体阳性患者血清 IFN γ为(53.17±17.13)pg/ml,阴性者为(34.57±10.34)pg/ml;阳性者血清 IFN- γ水平显著高于阴性者( t=2.36,P<0.05)。【结论】沙眼衣原体感染引起的输卵管炎症为输卵管不孕的主要原因,且检测血清 IFN -γ水平可能有利于无症状的沙眼依原体性输卵管炎症的诊断。

To explore the relationship between infection of Chlamydia trachomatis(CT) in tubal infertility and serum levels of IFN-γ.Chlamydiae trachomatis were detected by fluorogenic quantitative PCR, double-antibody sandwich ELISA was used to study the serum levels of interferon gamma(IFN-γ).The result showwed that 39 cases were positive and 12 cases were negative in CT. The serum levels of IFN-γ(pg/ml) in positive cases were 53.17±17.13, and those in negative cases were 34.57±10.34. There was a significant difference between two kinds of patients(t= 2.36,P<0.05) .[Conclusion]It is suggested that the infection of Chlamydia trachomatis is one of the major causes of tubal infertility. The levels of IFN-γ may be helpful to the diagnosis of Chlamydia trachomatis caused tubal infertility.