孕妇肝炎病毒及梅毒感染的流行病学研究及优生优育对策

Study on the Epidemiology of Hepatitis Virus and Syphilis of Pregnant women and Birth Health

【目的】研究粤东地区孕妇乙型、丙型、庚型肝炎病毒(HBV、HCV、HGV)及梅毒(RPR)感染的流行病学情况,探讨母婴传播的危险因素。【方法】应用酶联免疫吸附试验(ELISA)检测 HBV标志物六项、抗 HCV、抗 HGV;荧光定量聚合酶链式反应(FQ PCR)检测 HCV RNA、HGV RNA;RPR做梅毒血清学检测。【结果】1 836 例孕妇检测 HBsAg 阳性 268 例( 14. 6%); RPR 阳性 2 例( 0. 11%);抗 HCV 阳性 17 例(0.93%),其中12例HCV RNA阳性,所生12例婴儿2例阳性;240例孕妇检测抗 HGV阳性 6 例(2.5%),其中4例HGV RNA阳性,所生4例婴儿1例阳性。【结论】粤东地区孕妇以HBV感染为主。产道分娩或产后母乳喂养可能是HCV及HGV母婴传播危险因素。提倡采取预防保健措施达到优生优育。

To investigate the epidemiology of hepatitis B,C,G virus(HBV、 HCV、HGVW and syphilis in pregnant women in Yuedong and the risk factors of the mother-to-infant transmission.Enzyme-linked immunosorbent assay (ELISA) was used to test hepatitis B, anti-HCV, anti-HGV。 HCV-RNA and HGV-RNA were measured by FQ-PCR. RPR was used to test syphilis.In 1 836 normal pregnant women, 268(14.6%) were positive with HBsAg, 2(0.11%) with RPR , and 17(0.93%) with anti-HCV .Twelve of the 17 anti-HCV postitive women were HCV-RNA positive and two of their 12 infants were HCV-RNA positive .Six of 240 pregnant women were positive with anti-HGV ,four of the 6 women were positive with HGV-RNA, and one of the 4 infants was HGV-RNA positive.[Conclusion]HBV is major infections in pregnant women in Yuedong. Vagina delivery, breast-feeding are probably risk factors of mother-to-infant transmission of HGV and HCV. The preventive measure showuld be taken to protect health of the pregnant mothers and thier infants.